C-Stem™ technology: Scaling-up iPS-derived cell therapy
C-Stem™ technology: Scaling-up iPS-derived cell therapy
TreeFrog Therapeutics has developed C-Stem, a technology allowing for the mass-production of iPS-derived cell therapies in large-scale bioreactors. C-stem is based on a proprietary high-throughput cell encapsulation technology which generates over 1,000 capsules per second. Each stem cell capsule constitutes a biomimetic micro-environment which recapitulates an in-vivo like stem cell niche. In the capsule, pluripotent stem cells self-organize to form an epiblast-like 3D stem cell microtissue which promotes exponential pluripotent stem cell growth, maintenance of homogenous pluripotency and high-fidelity chromosome segregation (preservation of genomic integrity). But the capsule is also protecting stem cells during manufacturing proceses. In fact, C-Stem allows for the scale-independent exponential amplification of hiPSCs and their differentiation into functional 3D microtissues in industrial bioreactors.
Pluripotent Stem Cell–Based Cancer Therapy: Promise and Challenges
Induced Pluripotent Stem Cells: Reprogramming Platforms and Applications in Cell Replacement Therapy
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Growth Factors for Induced Pluripotent Stem Cell Culturing - ACROBiosystems
Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling
Frontiers Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications
Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy - ScienceDirect
Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells
Regenerative medicine: current research and perspective in pediatric surgery